Trisomy 14: A Recurring Cytogenetic Abnormality Associated with Myeloid Disorders

Healegne Poirel Unité INSERM U301 and SDI No. 196541 CNRS, Instilut de Génétique Moléculaire, Paris; Laboratoire Central d'Hématologie, HoCpital Saint-Louis, Paris, France

Philippe Jonveaux Unité INSERM U301 and SDI No. 196541 CNRS, Instilut de Génétique Moléculaire, Paris; Laboratoire Central d'Hématologie, HoCpital Saint-Louis, Paris, France

Marie-Thearegse Daniel Laboratoire Central d'Hématologie, HoCpital Saint-Louis, Paris, France

Roland Berger Unité INSERM U301 and SDI No. 196541 CNRS, Instilut de Génétique Moléculaire, Paris

Abstract

Trisomy 14 as single karyotype aberration was detected in three patients, two with acute myeloblas-tic leukemia, AML-M2 type, and one with aplastic anemia. These new observations and the 28 previously reported cases confirm that trisomy 14 is a primary non random change, mostly confined to myeloid disorders.

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Trisomy 14: A Recurring Cytogenetic Abnormality Associated with Myeloid Disorders

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Trisomy 14: A Recurring Cytogenetic Abnormality Associated with Myeloid Disorders

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