Interferon-Alpha and its Effects on the Cytokine Cascade: A Pro- and Anti-Inflammatory Cytokine

Abstract

Interferon-alpha (IFNα) has emerged as an important regulator of growth and differentiation, affecting cellular communication and signal transduction pathways as well as immunological control. The efficacy of IFNα has been demonstrated in many different diseases of viral, malignant, angiogenic, allergic, inflammatory, and fibrotic origin. Cytokines are pleiotropic and redundant molecules showing a wide variety of biologic functions on various tissues and cells, and several different cytokines exert similar and overlapping functions on certain cells. Data gained in the last years support this view also for IFNα. Initially thought to have mainly immunomodulating and proinflammatory effects, recent data suggest that IFNα has several anti-inflammatory properties. These newly identified antiinflammatory and immunosuppressive functions may help to explain some of the IFN mechanisms.

Key Words:

• Interferon
• alpha
• cytokine
• cascade
• cytokine
• pro-inflammatory
• anti-inflammatory