Bcl-x Gene Expression in Hodgkin's Disease

Daniel Schlaifer Service d'Hématologic Clinique Dieulafoy, Centre Hospitalier Universitaire, Hôpital de Purpart, Place du Docteur Baylac, 31059, Toulouse Cedex, France

Stanislaw Krajewski La Jolla Cancer Research Foundation, 10901 N. Torrey Pines Rd., La Jolla, CA, 92037, USA

Françoise Rigal-Huguet Service d'Hématologic Clinique Dieulafoy, Centre Hospitalier Universitaire, Hôpital de Purpart, Place du Docteur Baylac, 31059, Toulouse Cedex, France

Guy Laurent Service d'Hématologic Clinique Dieulafoy, Centre Hospitalier Universitaire, Hôpital de Purpart, Place du Docteur Baylac, 31059, Toulouse Cedex, France

Jacques Pris Service d'Hématologic Clinique Dieulafoy, Centre Hospitalier Universitaire, Hôpital de Purpart, Place du Docteur Baylac, 31059, Toulouse Cedex, France

Georges Delsol Laboratoire d'Anatomie-Pathologique and CIGH/CNRS, Centre Hospitalier Universitaire, Hôpital de Purpan, Place du Docteur Baylac, 31059, Toulouse Cedex, France

John C. Reed La Jolla Cancer Research Foundation, 10901 N. Torrey Pines Rd., La Jolla, CA, 92037, USA

Pierre Brousset Laboratoire d'Anatomie-Pathologique and CIGH/CNRS, Centre Hospitalier Universitaire, Hôpital de Purpan, Place du Docteur Baylac, 31059, Toulouse Cedex, France

show all

Abstract

Bcl-x is a Bcl-2-family protein that has been previously detected in cortical thymocytes, plasma cells, and activated lymphocytes. We report here on the high detection rate of the Bcl-x protein found in 86% of Hodgkin's disease samples and on the significance regarding its complex role among the Bcl-2-family of proteins: Bcl-x is known to heterodimerize with Bcl-2 (an anti-apoptosis protein) and with Bax, a potent inducer of cell death. Morover, recent evidences show that Bcl-x may induce multiple drug resistance in vitro, suggesting that chemical or biological interactions with this protein may have potential therapeutic value in Hodgkin's disease.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Bcl-x Gene Expression in Hodgkin's Disease

Information for

Open access

Opportunities

Help and information

Bcl-x Gene Expression in Hodgkin's Disease

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature