Brief Report: Stepdown Single Agent Antibiotic Therapy for the Management of the High Risk Neutropenic Adult with Hematologic Malignancies

Abstract

The standard of therapy for the high risk adult neutropenic host being treated with broad spectrum antibiotics for fever has been to continue intravenous antibiotics until neutropenia resolves. We performed a small, limited pilot study to determine if it is safe to switch these patients to oral monotherapy with ciprofloxacin. Ten patients with hematologic malignancies who had ⩽ 108 granulocytes/mm³ after cytoreductive therapy and were afebrile for at least five days had intravenous antibiotics discontinued and were placed on oral ciprofloxacin. Eight patients were able to be discharged hospital and seven were treated without the need for reinstitution of intravenous therapy. Of the three failures, one developed fever with a new bloodstream infection and two developed fever with relapse of leukemia. Patients remained on ciprofloxacin an average of 14.5 days (range 4 to 35 days). Aggregate cost savings for the 10 patients from this approach were estimated to be $11,400 for antibiotics and $88,800 for hospitalization. If corroborated in larger, randomized studies, the use of “stepdown monotherapy” may be a cost effective approach to the management of the stable neutropenic patient.

Key Words:

• neutropenia
• antibiotics
• sequential
• therapy
• hematologic
• malignancies