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Leukemia & Lymphoma Volume 23, 1996 - Issue 5-6
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Original Article

Molecular Cytogenetics of t(12;21)(p13;q22)

O. A. Bernard U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM) and SDI No. 15954 1 CNRS, Institut de Génétique Moléculaire, Paris, France
,
S. P. Romana U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM) and SDI No. 15954 1 CNRS, Institut de Génétique Moléculaire, Paris, France
,
H. Poirel U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM) and SDI No. 15954 1 CNRS, Institut de Génétique Moléculaire, Paris, France
&
R. Berger U 301 de l'Institut National de la Santé et de la Recherche Médicale (INSERM) and SDI No. 15954 1 CNRS, Institut de Génétique Moléculaire, Paris, France
Pages 459-465 | Received 16 Mar 1996, Published online: 01 Jul 2009
 
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Abstract

The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic leukemia (ALL) which fuses the TEL and AML1 genes, normally localized to 12p13 and 21q22, respectively. The crucial chimeric gene, TEL-AML1, is transcribed from the der(21) and encodes the 336 NH2 aminoacids of TEL fused to the majority of the AML1 protein. The t(12;21) is very often associated with loss of the normal, untranslocated TEL allele. These various aspects are presented here.

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