Occurrence of Myeloma in a Chronic Lymphocytic Leukemia Patient After Response to Differentiation Therapy with Interleukin-4

Della Makower Department of Oncology, Albert Einstein Cancer Center and Montefiore Medical Center, 111 East 210th Street, Bronx, New York, USA

Usha Venkatraj Department of Oncology, Albert Einstein Cancer Center and Montefiore Medical Center, 111 East 210th Street, Bronx, New York, USA

Janice P. Dutcher Department of Oncology, Albert Einstein Cancer Center and Montefiore Medical Center, 111 East 210th Street, Bronx, New York, USA

Peter H. Wiernik Department of Oncology, Albert Einstein Cancer Center and Montefiore Medical Center, 111 East 210th Street, Bronx, New York, USA

Abstract

The occurrence of chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) in a single individual is rare, and the clonal relationship between the two neoplasms is unclear. We describe here a patient with CLL who developed symptoms of MM while responding to experimental therapy with interleukin-4 (IL-4). This patient was treated with 2-chlorodeoxyadenosine (2-CDA), and had a response in both malignancies.

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Occurrence of Myeloma in a Chronic Lymphocytic Leukemia Patient After Response to Differentiation Therapy with Interleukin-4

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Occurrence of Myeloma in a Chronic Lymphocytic Leukemia Patient After Response to Differentiation Therapy with Interleukin-4

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