PRAD1/Cyclin D1 Gene Overexpression in Mantle Cell Lymphoma

Kouji Oka The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Toshiyuki Ohno The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Motoko Yamaguchi The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Nadim Mahmud The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Hiroshi Miwa The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Kenkichi Kita The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Hiroshi Shiku The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

Shigeru Shirakawa The Second Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu, Mie, Japan

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Abstract

The t(11;14) (q13;q32) translocation and its molecular counterpart Bcl-1 rearrangement are consistent features of mantle cell lymphoma (MCL). This translocation activates the PRAD1/cyclin D1 gene that is considered to be the Bcl-1 oncogene. PRAD1/cyclin D1 gene overexpression is closely associated with MCL. The PRAD1/cyclin D1 protein is localized to the nucleus, and the strong correlation between PRAD1/cyclin D1 and MCL is also found in the protein level. This finding indicates that PRAD1/cyclin D1 expression is a highly specific and sensitive molecular marker for MCL. This gene may function as an oncogene in the malignant transformation of cells.

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PRAD1/Cyclin D1 Gene Overexpression in Mantle Cell Lymphoma

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PRAD1/Cyclin D1 Gene Overexpression in Mantle Cell Lymphoma

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