Translocation t(8;16)(p11;p13) in Acute Non-Lymphocytic Leukemia: Report on Two New Cases and Review of the Literature

Elvira Rodrigues Pereira Velloso Center for Human Genetics, University of Perugia, Italy

Cristina Mecucci Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy

Lucienne Michaux Center for Human Genetics, University of Perugia, Italy

Angeline Van Orshoven Department of Clinical Biology, University of Perugia, Italy

Michel Stul Center for Human Genetics, University of Perugia, Italy

Marc Boogaerts Department of Hematology, University of Leuven, Italy

AndrÉ Bosly Department of Hematology, University of Louvain, Yvoir, Belgium

Jean-Jacques Cassiman Center for Human Genetics, University of Perugia, Italy

Herman Van Den Berghe Center for Human Genetics, University of Perugia, Italy

show all

Abstract

Two new cases of t(8;16)(p11;p13) in acute nonlymphocytic leukemia (ANLL) are described. These two patients in addition to the 34 previously described, showed a striking association with myelomonocytic (M4) or monocytic (M5) leukemia, extramedullary infiltration, erythrophagocytosis and disseminated intravascular coagulation. One of our patients showed a TCRβ gene rearrangement. Alltogether 36 cases of t(8;16) ANLL have been documented until today. We here review their clinical and cytogenetic features.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Translocation t(8;16)(p11;p13) in Acute Non-Lymphocytic Leukemia: Report on Two New Cases and Review of the Literature

Information for

Open access

Opportunities

Help and information

Translocation t(8;16)(p11;p13) in Acute Non-Lymphocytic Leukemia: Report on Two New Cases and Review of the Literature

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature