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Leukemia & Lymphoma Volume 25, 1997 - Issue 1-2
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Original Article

Mitotic Activity and Nuclear DNA Damage of Large Cells in Hodgkin's Disease: Comparison with the Expression of p53 and bcl-2 Proteins and the Presence of Epstein-Barr Virus

Lorenzo Leoncini Institute of Pathologic Anatomy and Histology, University of Siena, Strada delle Scotte, 6, 1–53100, Siena, Italy
,
Donatella Spina Institute of Pathologic Anatomy and Histology, University of Siena, Strada delle Scotte, 6, 1–53100, Siena, Italy
,
Pauline Close Department of Anatomical Pathology, University of Cape Town, South Africa
,
Chiara Minaccp Institute of Pathologic Anatomy and Histology, University of Siena, Strada delle Scotte, 6, 1–53100, Siena, Italy
,
Tiziana Megha Institute of Pathologic Anatomy and Histology, University of Siena, Strada delle Scotte, 6, 1–53100, Siena, Italy
,
Fabio de Luca Unit of Hemolymphopathology, 2nd Service of Pathologic Anatomy, Institute of Hematology “L. & A. Seràgnoli”, University of Bologna, Italy
,
Piero Tosp Institute of Pathologic Anatomy and Histology, University of Siena, Strada delle Scotte, 6, 1–53100, Siena, Italy
,
Stefano Pileri Unit of Hemolymphopathology, 2nd Service of Pathologic Anatomy, Institute of Hematology “L. & A. Seràgnoli”, University of Bologna, Italy
,
Rainer Kraft Institute of Pathology, University of Berne, Switzerland
,
Jean A. Laissue Institute of Pathology, University of Berne, Switzerland
&
Hans Cottier Institute of Pathology, University of Berne, Switzerland
 show all
Pages 153-161 | Accepted 30 May 1996, Published online: 01 Jul 2009
 
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Abstract

The roles of the bcl-2 and p53 proteins in Hodgkin's disease (HD) are poorly understood. We therefore compared their detected presence in Hodgkin and Reed-Sternberg/large atypical (H-RS/LA) cells immunohistochemically with the percentages of these cells double-labeled for CD30 and DNA strand breaks (DNA fragmentation index, DFI); mitotic indices (MI); and the EBV infection status. We found a highly significant inverse correlation between the fractions per case of H-RS/LA cells expressing bcl-2/p53 proteins and the DFI of CD30+ elements. No marked effect of these two oncoproteins on MI was noticed, although these parameters and DFI of CD30+ cells were linearly related. EBV infection of H-RS/LA cells exerted only a limited effect on the parameters tested. The results of this study suggest that overexpressed bcl-2 and, to some extent, p53 proteins in H-RS/LA cells of HD primarily counteract deletion of these cells.

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