Acute Promyelocytic Leukemia in a HIV Seropositive Patient

R. Calvo Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

J. M. Ribera Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

M. Battle Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

J. M. Sancho Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

I. Granada Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

A. Floes Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

F. MillÁ Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

E. Feliu Hematology Department, Hospital Universitari Germans Trim i Pujol., c/ Canyet s/n 08916 Badalona, Universitat Autdnoma of Barcelona, Spain

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Abstract

Acute myeloid leukemia (AML) is infrequent in patients with human immunodeficiency virus (HIV) infection. Among AML, acute promyelocytic leukemia (APL) has been rarely described in such patients, with only one case being published. We report a 30 years-old intravenous drug abuser HIV-infected male with APL who attained complete clinical, morphological, and molecular remission after differentiation therapy with all-trans-retinoic acid (ATRA) followed by intensive chemotherapy. The results of treatment in this patient and in other AML published cases suggest that therapy for AML should not be modified because of HIV infection if patients have an adequate performance status.

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Acute Promyelocytic Leukemia in a HIV Seropositive Patient

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