Advanced search
Publication Cover
Leukemia & Lymphoma Volume 27, 1997 - Issue 3-4
Submit an article Journal homepage
39
Views
1
CrossRef citations to date
0
Altmetric
Original Article

A Translocation t(8;14) and c-myc Gene Rearrangement Associated with the Histological Transformation of B-cell Acute Lymphocytic Leukemia (FAB-L2) into Burkitt's Type (FAB-L3) Leukemia

Nobuo Masauzi Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan; The Third Department of Internal Medicine, Hokkaido, University School of Medicine, Sapporo, Japan
,
Masaharu Kasai Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Gak Suzuki Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Naoki Kobayashi Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Hiroko Ohizumi Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Masahiro Ogasawara Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Yoshio Kiyama Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Tohru Naohara Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Masao Saitoh The Third Department of Internal Medicine, Hokkaido, University School of Medicine, Sapporo, Japan
,
Toshio Higa Department of Internal Medicine, Sapporo Hokuyu Hospital Artificial Organs & Transplantation Research Institute, Higashisapporo 6-6, Shiroishi-ku, Sapporo 003Japan
,
Junji Tanaka The Third Department of Internal Medicine, Hokkaido, University School of Medicine, Sapporo, Japan
,
Satoshi Hashino The Third Department of Internal Medicine, Hokkaido, University School of Medicine, Sapporo, Japan
,
Masahiro Imamura The Third Department of Internal Medicine, Hokkaido, University School of Medicine, Sapporo, Japan
&
Masahiro Asaka The Third Department of Internal Medicine, Hokkaido, University School of Medicine, Sapporo, Japan
 show all
Pages 357-363 | Received 10 Jul 1996, Published online: 01 Jul 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

We report a case of B-cell acute lymphocytic leukemia which showed histological transformation from an FAB-L2 into a Burkitt's type (FAB-L3). Both leukemias had identical immunoglobulin heavy-chain joining gene and kappa light-chain joining gene rearrangements, indicating the clonal identity of the two leukemias. A chromosomal analysis of leukemia cells on the onset indicated normal karyotype, whereas that of the transformed FAB-L3 showed t(8;14) (q24;q32). Furthermore, the proto-oncogene c-myc was in the germline configuration in the initial leukemia but in the rearranged configuration after transformation. Presence of t(8;14) (q24;q32) and the c-myc gene rearrangement after transformation suggested that the chromosomal translocation followed by the activation of the c-myc proto-oncogene might be involved in the Burkitt's type transformation of the FAB-L2 leukemic clone, but not in the leukemogenesis of the initial FAB-L2 leukemia.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.