Low levels of serum soluble c-Kit relates to delayed engraftment after bone marrow transplantation

Satoshi Hashino The Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan

Masahiro Imamura The Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan; The Division of Internal Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan

Junji Tanaka The Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan; The Division of Internal Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan

Sumiko Kobayashi The Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan; The Division of Internal Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan

Masaharu Kasai The Division of Internal Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan

Keisuke Sakurada The Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan; The Division of Internal Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan

Masahiro Asaka The Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan; The Division of Internal Medicine, Sapporo Hokuyu Hospital, Sapporo, Japan

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Abstract

Serum soluble c-kit concentrations were measured in 28 patients undergoing bone marrow transplantation (BMT). The c-kit levels in patients with delayed engraftment (time to leukocyte recovery > 1.0 × 10⁹/L being more than 20 days after BMT) were significantly lower than those in patients with early engraftment (time to leukocyte recovery being less than 19 days after BMT) from the start of conditioning until day 100 after BMT. The data from this study indicates that the measurement of serum soluble c-kit concentrations may be a useful indicator of engraftment.

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Low levels of serum soluble c-Kit relates to delayed engraftment after bone marrow transplantation

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Low levels of serum soluble c-Kit relates to delayed engraftment after bone marrow transplantation

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