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Original Article

Acute Myelomonoblastic Leukemia Carrying the PEBP2β/MYH11 Fusion Gene

, , , , , , , & show all
Pages 81-91 | Received 02 Dec 1997, Published online: 01 Jul 2009
 

Abstract

As recurrent chromosome abnormalities in leukemia are highly associated with particular subtypes, the genetic events of specific chromosome alteration must be associated with leukemo-genesis and characteristics of the disease. The chromosomal breakpoints involved in inv(16) and t(16;16) have been shown to generate the fusion gene PEBP2β(CBFβ)/MYH11. The PEBP2β/MYH11 fusion transcripts in all 8 patients with M4Eo, 2 of 18 with M4, and one CML in the blastic phase were detected by using RT-PCR and Southern blotting. We demonstrated the marked expression of CD34 and c-KIT (CD 117) antigens in myelomonoblastic leukemia cells from all patients carrying this fusion gene, which was in contrast to the patients with M4 but without the fusion gene. These results indicate that immunophenotypic analysis is useful for detection of leukemia with the fusion gene, and that the PEBP2β/MYH11 fusion gene is involved in immature cells expressing CD34 and c-KIT antigens.

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