Primary Cutaneous T-Cell Lymphoma Involving the Cheek: An Infant Case with a Unique Clinicopathologic Feature

Abstract

We report a clinicopathologic feature of primary cutaneous T-cell lymphoma (CTCL) in a five-year-old boy with increasing swelling of his cheek since two years of age. Histologically, an infiltrate of atypical lymphoid cells with mature T-cell phenotype and clonality was prominent from the dermis to the subcutaneous tissue of the cheek. Although little effect was seen with aggressive multidrug-combined chemotherapy, therapy with interferon-α and steroids achieved a prolonged remission. This patient may provide important clues to understanding the clinicopathologic feature of rare primary CTCL in young children.

Key Words:

• Swelling of the cheek
• cutaneous T-cell lymphoma
• immunophenotype
• TCR rearrangement