Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Banu Arun Division of Hematology/Oncology, Washington, DC, USA

Brenda Berberian Division of Dermatology, Washington, DC, USA

Norio Azumic Dept of Pathology Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, 20007, USA

Stanley R Frankela Division of Hematology/Oncology, Washington, DC, USA

Harvey Luksenburga Division of Hematology/Oncology, Washington, DC, USA

Carl Fretera Division of Hematology/Oncology, Washington, DC, USA

Abstract

A 46 year old male with acute promyelocytic leukemia treated with all-trans retinoic acid (ATRA), developed fever, bilateral erythematous nodules in his axillary area, lower abdomen and inguinal region. Histopathologic examination of the skin biopsy revealed dense neutrophil infiltration in the dermis without vasculitis. The diagnosis of Sweet's syndrome was made. High dose methylprednisolone was administered and the lesions started to improve within 24 hours.

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Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

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Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

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