T-Cell-Rich B-Cell Non-Hodgkin's Lymphoma Mimicking Hodgkin's Disease

B. Bättig Institute of Medical Oncology, Inselspital, University of Berne, 3010, Bert

E. Mueller-garamvoelgyi Institute of Pathology, Inselspital, University of Berne, 3010, Bert

S.-B. Cogliatti Institute of Pathology, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland

U. Schmid Institute of Pathology, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland

A. Kappeler Institute of Pathology, Inselspital, University of Berne, 3010, Bert

Th. Cerny Medical Clinic C, Kantonsspital, St. Gallen, Rorschacherstrasse 95, 9007, St. Gallen, Switzerland

J.-A. Laissue Institute of Pathology, Inselspital, University of Berne, 3010, Bert

M.-F. Fey Institute of Medical Oncology, Inselspital, University of Berne, 3010, BertCorrespondence[email protected]

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Abstract

We report on a patient with recurrent T-cell-rich B-cell lymphoma (TCRBCL), initially misdiagnosed as a lymphocyte-rich Hodgkin's disease. This case exemplifies the diagnostic problems of TCRBCL and the need for immunophenotypic analysis to differentiate TCRBCL from Hodgkin's disease, nodular paragranuloma and peripheral T-cell lymphoma. A rather unusual aspect is the long disease-free interval between the excision of the node in and the late relapse in 1996. The significance of the abundant T-cell infiltration in this B-cell neoplasm will be discussed and the concepts concerning antitumor response will be reviewed. Based on epidemiological data and the clinical behaviour TCRBCL does not seem to represent a distinctive pathological entity.

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T-Cell-Rich B-Cell Non-Hodgkin's Lymphoma Mimicking Hodgkin's Disease

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T-Cell-Rich B-Cell Non-Hodgkin's Lymphoma Mimicking Hodgkin's Disease

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