Aml1/ETO and Pml/RARA Rearrangements in a Case of AML-M2 Acute Myeloblastic Leukemia with t(15;17)

Marileila Varella-garcia University of Colorado Health Sciences Center, Cancer Center and Division of Medical Oncology, Denver, Colorado, USA

FranÇOise Brizard Laboratoire d'Hématologic ESA CNRS 6031, Centre Hospitaller Universitaire, Poitiers, France

JoËLle Roche IBMIG, ESA CNRS 6031, Université de Poitiers, Poitiers, France

Georges Flandrin Laboratoire d'Hématologic Hopital Necker, Paris, France

Harry Drabkin University of Colorado Health Sciences Center, Cancer Center and Division of Medical Oncology, Denver, Colorado, USA

AndrÉ Brizard Laboratoire d'Hématologic ESA CNRS 6031, Centre Hospitaller Universitaire, Poitiers, France

Abstract

We report a case of acute myeloid leukemia FAB-type 2 with a translocation t(15;17)(q22;q12) On the basis of the cytological findings, a translocation t(8;21)(q22;q22) was suspected. FISH analyses using specific probes for t(15;17) and t(8;21) detected both PML/RARα and AML1/ETO rearrangements in a few percentage of cells. This case demonstrates the complexities that may occur between cytology and cytogenetic findings and the usefulness of FISH methods to detect an AML1/ETO rearrangement only suspected by cytological examination of bone marrow smears.

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Aml1/ETO and Pml/RARA Rearrangements in a Case of AML-M2 Acute Myeloblastic Leukemia with t(15;17)

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Aml1/ETO and Pml/RARA Rearrangements in a Case of AML-M2 Acute Myeloblastic Leukemia with t(15;17)

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