Thrombocytosis With Sideroblastic Erythropoiesis: A Mixed Myeloproliferative Myelodysplastic Syndrome

Abstract

Some patients with haematological neoplasms have features which overlap between a myelodysplastic syndrome and a myeloproliferative disorder. Two such patients are reported, both having sideroblastic erythropoiesis and thrombocytosis and one sequentially developing features of atypical chronic myeloid leukaemia, idiopathic myelofibrosis and acute megakaryo-blastic leukaemia. The prevalence of thrombocytosis among cases of refractory anaemia with ring sideroblasts may be as high as 15–20% and has implications for choice of therapy.

Key Words:

• myelodysplastic syndromes
• myeloproliferative disorders
• sideroblastic erythropoiesis
• thrombocytosis