Cytotoxicity of 2-Chlorodeoxadenosine (Cladribine, 2-cdA) in Combination with other Chemotherapy Drugs Against two Lymphoma Cell Lines

Mark Hoffman From the Division of Hematology-Oncology, Department of Medicine, Long Island Jewish Medical Center campus of the Albert Einstein College of Medicine, New Hyde Park, New YorkCorrespondence[email protected]

Jing Chu Xu From the Division of Hematology-Oncology, Department of Medicine, Long Island Jewish Medical Center campus of the Albert Einstein College of Medicine, New Hyde Park, New York

Martin Lesser From the Division of Hematology-Oncology, Department of Medicine, Long Island Jewish Medical Center campus of the Albert Einstein College of Medicine, New Hyde Park, New York

Kanti Rai the Division of Biostatistics, North Shore Hospital, Manhasset, New York, USA

Abstract

Cladribine is a purine analog with impressive activity in patients with low-grade lymphoproliferative disorders. We studied the combination of cladribine with other antineoplastic drugs against two human-derived B-cell lymphoma cell lines in vitro. Cladribine was combined with cisplatin, daunorubicin, chlorambucil, paclitaxel or etoposide. Under the experimental conditions studied, only the combination of cladribine and cisplatin showed significantly increased cytotoxicity compared to the effect of either drug alone.

Key Words:

cladribine cytotoxicity lymphoma drug combinations

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Cytotoxicity of 2-Chlorodeoxadenosine (Cladribine, 2-cdA) in Combination with other Chemotherapy Drugs Against two Lymphoma Cell Lines

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Cytotoxicity of 2-Chlorodeoxadenosine (Cladribine, 2-cdA) in Combination with other Chemotherapy Drugs Against two Lymphoma Cell Lines

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