Can Propofol Cause Dystonia and Movement Disorders?

Abstract

Abnormal movement disorders have been reported in association with the use of propofol for the induction and maintenance of general anesthesia. These movements were described as involuntary movement and dystonia.¹ The dystonia are clinically and genetically different group of disorders with a variety of causes.² There are numerous studies about the cause of dystonia due to propofol use. We attempted to evaluate critically published cases of propofol-induced dystonia and similar movement disorders. The proposed mechanisms and pathophysiology of this reaction will be analyzed. Expected patient outcomes and recommendations for proper management of such reactions are presented. We hope that this article guides clinicians to provide better care for their patients.