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Endothelium
Journal of Endothelial Cell Research
Volume 3, 1995 - Issue 2
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Original Article

Endocrine Effects of Endothelin-I

Pages 113-120 | Received 05 Sep 1994, Published online: 13 Jul 2009
 

Abstract

Due to increased secretion and /or a reduced clearance rate plasma concentrations of endothelin-1 are, in a variety of pathological conditions, in the same range as those induced by the peptide's exogenous administration. While the currently available evidence nicely demonstrates that endothelins exert pharmacologic effects in virtually every endocrine system studied so far it is, at this point, difficult to assess the physiological and pathophysiological relevance of these observations. The advent of clinically applicable endothelin-antagonists hopefully will provide a new tool to approach this yet unsolved question.

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