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Abstract
Objective: The aim of this study is to summarize the reported evidence on the possible relationship between preeclampsia, placenta, oxidative stress and plasma membrane Ca-ATPase (PMCA) activity, responsible for fine control of intracellular calcium concentration. Methods: Literature search was conducted in MEDLINE/PubMed and several unpublished results from our laboratory were included. Results: Lipid peroxidation in placental and red blood cell plasma membranes during preeclampsia and a concomitant diminution of their PMCA activity are described. Conclusions: Uteroplacental hypoperfusion raises lipid peroxidation by-products in the blood plasma that could alter structure and functionality of the cell membranes of the endothelium and several tissues.
ACKNOWLEDGMENTS
This study was supported in part by grant no. H9/181/R427, project 96350, from the World Health Organization and by grant from FONACIT-Venezuela no. F-2005000222.
Declaration of Interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.