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Hypertension in Pregnancy Volume 32, 2013 - Issue 1
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Research Article

Effect of l-Arginine Supplementation on Blood Pressure in Pregnant Women: A Meta-Analysis of Placebo-Controlled Trials

Qing ZhuKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR China
,
Xin YueKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR China
,
Qing-Yin TianKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR China
,
Gaowa SarenKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR China
,
Ming-Hui WuKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR China
,
Yun ZhangKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR China
&
Tong-Tao LiuKey Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan, PR China;Department of Cardiology, QiLu Hospital, Shandong University, Jinan, PR ChinaCorrespondence[email protected]
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Pages 32-41 | Published online: 07 Sep 2012
 
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Abstract

Objective. A meta-analysis of placebo-controlled trials was conducted to evaluate the effect of l-arginine supplementation on blood pressure (BP) in pregnancy. Methods. Trials were searched in PubMed, Embase, and Cochrane Library. A total of five trials were included in the meta-analysis. Results. l-Arginine supplementation exhibited a mean decrease of 3.07 mmHg (p = 0.004) for diastolic blood pressure and a mean increase of 1.23 weeks (p = 0.002) for gestation age at delivery in pregnancy, but did not reduce systolic BP (p = 0.19) as compared to placebo. Conclusion. l-Arginine supplementation had a significant effect of lowering diastolic blood pressure and prolonging gestation age in pregnancy.

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