Elevated serum angiopoietin-like protein 6 in women with subsequent pregnancy-induced hypertension: a preliminary study

Abstract

Objective: Association of maternal angiopoietin-like protein 6 (Angptl6) levels with subsequent development of pregnancy-induced hypertension (PIH). Methods: At 24 and 32 weeks of gestation in 47 relatively overweight (BMI ≥ 24 kg/m²), nulliparous pregnant women serum concentrations of Angptl6 were quantified prospectively. Insulin sensitivity and lipids were measured at 24 weeks. Results: Angptl6 levels at 24 weeks, but not at 32 weeks, were significantly higher in women with subsequent PIH. Metabolic factors at 24 weeks did not correlate with Angptl6 levels. Conclusion: This preliminary study suggests that in the second trimester, Angptl6 levels are higher in women with subsequent PIH.

• Angiopoietin-like protein 6
• Insulin sensitivity
• Preeclampsia
• Pregnancy-induced hypertension.