Combined biomarkers evaluation for diagnosing kidney injury in preeclampsia

Abstract

Objective: To identify novel potential biomarkers and evaluate combined biomarkers for diagnosing kidney injury with considerable accuracy in preeclampsia. Methods: The level of serum and urine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), retinol-binding protein (RBP) and interleukin-18 (IL-18) were measured by enzyme-linked immunosorbent assay. Results: The level of serum cystatin C, urine RBP, urine NGAL and urine KIM-1 in preeclampsia group were higher than that in the normal pregnancy group. When four biomarkers are combined, the sensitivity and specificity are 100%/98.20%. Conclusion: Urine KIM-1 is the most potential biomarker for renal injury in preeclampsia. The more biomarkers combined, the more sensitivity and specificity were increased.

• Biomarkers
• Preeclampsia
• Gestational hypertension
• Kidney injury
• Kidney injury molecule-1

Acknowledgements

The authors sincerely thank the staffs from the Department of Gynaecology and Obstetrics, The Fifth People’s Hospital of Shanghai, Fudan University, People’s Republic of China, for their help with sample collection.