Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review

Reuben TangDepartment of Maternal-Fetal medicine, Royal Hospital for Women, Sydney, Australia, Correspondence[email protected]

Ing Ching TangDepartment of Obstetrics and Gynaecology, Rejang Medical Centre, Sibu, Malaysia,

Amanda HenryDepartment of Maternal-Fetal medicine, Royal Hospital for Women, Sydney, Australia, ;School of Women’s and Children’s Health, UNSW Medicine, University of New South Wale, Randwick, NSW, Australia, ;Department of Obstetrics & Gynaecology, St. George Public Hospital, Sydney, Australia, and

Alec WelshDepartment of Maternal-Fetal medicine, Royal Hospital for Women, Sydney, Australia, ;School of Women’s and Children’s Health, UNSW Medicine, University of New South Wale, Randwick, NSW, Australia, ;Australian Centre for Perinatal Science, University of New South Wales, Sydney, NSW, Australia

Abstract

Objective: This article synthesises evidence for calcium supplementation in preeclampsia prevention. Methods: Major databases and trial registries were searched, and comparisons were made against other meta-analyses. Results: Calcium supplementation reduced the overall risk of preeclampsia in 10 trials (n = 24 787; risk ratio (RR) 0.62; 95% confidence interval [CI] 0.47–0.81). Its effect was larger in two subgroups: low-baseline calcium intake (RR 0.42 [0.23–0.76]) and increased risk of developing hypertensive disorders (RR 0.36 [0.10–0.98]). This effect was not significant amongst larger studies (RR 0.93 [0.83–1.04]). Funnel plotting suggested possible publication bias. Conclusion: Some evidence for calcium supplementation exists, but its utility is limited by the possibility of publication bias and a lack of large trials.

Keywords

Declaration of interest

No potential conflicts of interest are declared.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review

Information for

Open access

Opportunities

Help and information

Limited evidence for calcium supplementation in preeclampsia prevention: a meta-analysis and systematic review

Abstract

Declaration of interest

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature