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Abstract
Objective: To determine the serum thiol/disulphide homeostasis in preeclampsia and to investigate the association with clinical parameters. Methods: Forty-three pregnant women with preeclampsia and 43 healthy, uncomplicated pregnancies were included in the study. Native thiol, disulphide, and total thiol concentrations were measured by a novel automated method. Results: The serum native and total thiol levels were significantly lower in preeclampsia when compared with the healthy group (p < 0.001). There were significant correlations among the homeostatic parameters and preeclampsia. Conclusion: Serum thiol/disulphide homeostasis may have a role in the pathogenesis and can be evaluated with the clinical and laboratory findings of preeclampsia.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper