Comparison of serum zinc, calcium, and magnesium concentrations in women with pregnancy-induced hypertension and healthy pregnant women: A meta-analysis

ABSTRACT

Objective: The relationship between serum zinc, magnesium, and calcium levels and pregnancy-induced hypertension (PIH) is controversial. The aim of our study was to determine whether or not serum zinc, magnesium, and calcium levels are associated with PIH. Methods: In our study, we searched databases, including Wangfang, Chinese National Knowledge Infrastructure, and PubMed, to find literature regarding the relationship between PIH and serum trace elements. Meta-analysis was performed using the Review Manager5.3 software. Results: A total of 14 articles were included in our study. The results of the meta-analysis indicated that patients with PIH had lower serum zinc (SMD = −1.14; 95% CI] = −1.69, −0.59; P < 0.05), calcium (MD = −0.26; 95% CI = −0.36, −0.15; P < 0.05), and magnesium concentration (MD = −0.0.06; 95% CI = −0.08, −0.05; P < 0.05) than healthy gravidas. Conclusion: Our research suggests that serum zinc, calcium, and magnesium concentrations may have an effect on PIH. Thus, the serum zinc, calcium, and magnesium levels could be measured for PIH patients.

KEYWORDS:

• Calcium
• case-control study
• hypertension
• magnesium
• zinc

Declaration of interest

The authors report no conflicts of interest.

Funding

This research was supported by Wannan Medical College Key Scientific Research Projects Engagement Fund (WK2014Z05) and Anhui Provincial Undergraduate Training Programs for Innovation and Entrepreneurship (No. AH201310368102 and 201510368134).

Additional information

Funding

This research was supported by Wannan Medical College Key Scientific Research Projects Engagement Fund (WK2014Z05) and Anhui Provincial Undergraduate Training Programs for Innovation and Entrepreneurship (No. AH201310368102 and 201510368134).