ABSTRACT
Objective: To evaluate the effect of genistein supplementation on the oxidative/nitrative stress and antioxidant capacity of normotensive and preeclamptic placental trophoblast. Methods: The stress status of placental trophoblast was assessed by measuring their respective markers before and after incubation with genistein. Results: A significant increase in stress along with decrease in antioxidant status was observed in preeclamptic placental trophoblast, whereas genistein incubation significantly alters oxidant-antioxidant status. Conclusion: The study revealed that genistein may play a significant role in controlling oxidative/nitrative stress during preeclampsia. Hence, genistein can be used as an effective dietary supplement for the treatment and management of preeclampsia.
Conflict of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.