Response of the Renin-Aldosterone System and Antidiuretic Hormone to Oral Water Loading and Hypertonic Saline Infusion During and after Pregnancy

M. B. Vallotton Division of Endocrinology, Laboratories of Clinical Investigation, University of Geneva, Hôpital Cantonal, Geneva, Switzerland; Department of Obstetrics, Gynecology and Medicine, University of Chicago, Chicago, Illinois, 60637, USA

J. M. Davison MRC Human Reproduction Group, Princess Mary Maternity Hospital, Newcastle upon Tyne, NE2 3BD

A. M. Riqndel Division of Endocrinology, Laboratories of Clinical Investigation, University of Geneva, Hôpital Cantonal, Geneva, Switzerland

And M.D. Lindheimer Senior International Fellow of the Fogarty International Center of the National Institutes of Health (F06TN00100) and a visiting Professor at the University of Geneva Medical School while this work was performed

Abstract

Amongst the many physiological changes in human pregnancy are the sustained stimulation of the renin-angiotensin system and a decrease in plasma osmolality (p_osm). In this study the effect osmolar and water loading on the renin-angiotensin system and arginine vasopressin (AVP) secretion has been tested in seven women during the third trimester and again 8-10 weeks after delivery.

Pregnant women had markedly increased plasma renin substrate (PRS), plasma renin activity (PRA) and plasma renin concentration (PRO values as well as aldosterone levels when compared to their post-partum values.

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Response of the Renin-Aldosterone System and Antidiuretic Hormone to Oral Water Loading and Hypertonic Saline Infusion During and after Pregnancy

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Response of the Renin-Aldosterone System and Antidiuretic Hormone to Oral Water Loading and Hypertonic Saline Infusion During and after Pregnancy

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