Prostaglandin E₂ and the Release of Renin from Human Chorion

Abstract

Sections of chorion laeve were perfused with a solution of medium E199 for five hours. Samples were collected every 20 minutes and the concentration of active and inactive renin in the perfusate was measured. The addition of prostaglandin E₂ (PGE₂)(10⁻⁶M to 10⁻⁴M) to the medium did not alter the concentration of active or inactive renin in the perfusate. Similarly, blockade of prostaglandin synthesis with indomethacin (10⁻⁴M to 10⁻³M) had no effect on the pattern of renin release. These results suggest that the E-series prostaglandins which are produced by the utero-placental unit do not stimulate the release of renin from human chorion