![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Objective: We tested whether indomethacin (IND) potentiates the elevation of blood pressure induced by the reduction of the uteroplacental perfusion pressure (RUPP).
Methods: In pregnant rabbits on the 21st day of the 30-day gestation, the uteroplacental perfusion pressure was reduced by 68 ± 5% using a clip placed on the abdominal aorta below the renal arteries. IND suppositories (15 mg/kg each) were administered 1 and 2 days following surgery.
Results: After the second dose, MAP of IND-treated RUPP rabbits was higher (92 ± 9 mm Hg, n = 10) than in those receiving placebo (78 ± 12, n = 9, P <. 01). MAP of sham-operated pregnant rabbits with or without IND was 61 ± 9 and 58 ± 8 mm Hg, respectively (NS). Placebo-treated RUPP animals evidenced an enhanced urinary sodium excretion as compared to nor-motensive control rabbits receiving placebo (3.27 ± 0.69 mmol/kg/day vs. 1.49 ± 0.74, P <. 001). Enhanced urinary sodium excretion was blunted by IND in RUPP rabbits (1.25 ± 0.37, P <. 001).
Conclusion: (1) IND potentiates the hypertensive response induced by RUPP. (2) the reduction of urinary sodium excretion may be one of the several pharmacological effects of IND aggravating hypertension in this state.