Effects of Exercise Therapy Alone and in Combination with a Calcium Channel Blocker or an Angiotensin Receptor Blocker in Hypertensive Patients

Abstract

We compared the effects of exercise alone and in combination with a calcium channel blocker (amlodipine) or an angiotensin receptor blocker (valsartan) in hypertensive patients. Our results indicated that exercise therapy exerted similar effects on systolic blood pressure whether administered alone or in combination with amlodipine or valsartan; however, diastolic blood pressure decreased significantly when exercise therapy was combined with amlodipine. However, when combined with valsartan, exercise therapy additionally improved the lipid profile of hypertensive patients. Thus, this study enabled the identification of the drugs suitable for combination with exercise therapy in the treatment of hypertensive patients.

• exercise therapy
• calcium channel blockers
• angiotensin receptor blockers
• lipid profile
• combination therapy

ACKNOWLEDGMENTS

We express our gratitude to the staff engaged in Fukuoka City Medical Association Hospital for their support of this study, and Ms. Tomoyo Omae for her excellent technical assistance. The content of this paper has been presented at the 34th Annual Scientific Meeting of the JSH.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.