Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model

Serap Cilaker MıcılıDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, TurkeyCorrespondence[email protected] [email protected]

Bekir Uğur ErgurDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Candan OzoğulDepartment of Histology and Embryology, Faculty of Medicine, Gazi University, Ankara, Turkey

Sülen SarıoğluDepartment of Pathology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

H. Alper BağrıyanıkDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Kazım TuğyanDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Cetin PekcetinDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Ulker SonmezDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Isıl TekmenDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Guven ErbilDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Gul Guner AkdoğanDepartment of Biochemistry, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Doğan OzyurtDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

Zisan BuldanDepartment of Histology and Embryology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey

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Abstract

In this study, experimental diabetes and nephrectomy have been applied separately and together in order to investigate the possible therapeutic effects of lipoic acid (LA) on hypertensive and diabetic rat kidneys. Wistar rats were divided into eight groups: control, diabetes mellitus (DM), 5/6 nephrectomy, DM + 5/6 nephrectomy, LA administration, DM + LA treated, 5/6 nephrectomy + LA treated, and DM + 5/6 nephrectomy + LA-treated groups, respectively. Renal damage was evaluated histomorphometrically, ultrastructurally, and biochemically. Our findings supported that diabetes and hypertension together increased the rate of renal injury, and LA had therapeutic effects on hypertensive and diabetic rat kidneys.

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ACKNOWLEDGMENT

The authors thank Bio. Özcan Üstün and Bio. Sedef Menkü for their assistance in the laboratory and Assistant Prof. Dr. Nergis Durmus from the Department of Pharmacology.

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Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model

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Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model

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