Modification of the liver fatty acids by Hibiscus sabdariffa Linnaeus (Malvaceae) infusion, its possible effect on vascular reactivity in a metabolic syndrome model

Abstract

We investigated the effects of Hibiscus sabdariffa Linnaeus (HSL)-fed infusion on the fatty acid (FA) profile in liver of metabolic syndrome (MS) rats and its possible effect on vascular reactivity. Body mass, intra-abdominal fat, triglycerides, insulin, blood pressure, saturated, monounsaturated FA, NEFAs, Δ⁹-, Δ⁶-desaturases and vasoconstriction were increased, while vasorelaxation, polyunsaturated FA, endothelial nitric oxide and / ratio decreased in MS versus Control, but HSL infusion modified it and increased Δ⁵-desaturase. The results suggest that the alteration in FA liver metabolism in the MS contributes to impaired vascular reactivity, but treatment with of HSL infusion can improve this condition.

• Desaturases
• Hibiscus sabdariffa Linnaeus
• liver fat
• metabolic syndrome
• non-esterified fatty acids
• vascular reactivity

Acknowledgements

We thank Rodrigo Velázquez Espejel for technical support in immunoblotting and Marco Antonio Rosas for technical support in the care of the experimental groups.