Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus

ABSTRACT

Experimental models recently suggested an interaction between aldosterone and adipose tissue, but clinical investigation has been limited. We studied the effects of eplerenone compared to hydrochlorothiazide (HCTZ) on blood pressure (BP), glucose, and lipid levels in 50 patients with essential hypertension (EHT) and type 2 diabetes mellitus whose BP failed to reach target levels with 8 mg of candesartan alone. BP improved similarly in both groups over the 12-month study period, but BMI, waist circumference, and LDL-cholesterol were decreased in the eplerenone group, while glycohemoglobin was elevated in the HCTZ group.

KEYWORDS:

• Aldosterone
• adiponectin
• combination therapy
• diabetes
• eplerenone

Acknowledgments

We thank the hospital staff in Kanazawa Insurance hospitals for their help with the data collection.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This work was partially supported by the Health and Labor Sciences Research Grant of Japan.

Additional information

Funding

This work was partially supported by the Health and Labor Sciences Research Grant of Japan.