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Abstract
The general cardiovascular-autonomic profiles of prazosin (PR) and phentolamine (PH) were compared. Antihypertensive activity was evaluated in conscious spontaneously hypertensive rats (SHR) using single oral doses of either agent. PR (0.01 -30 mg/kg, p.o.) caused dose-dependent reductions in mean aortic blood pressure (BP) (δ -13± 5 to δ -61± 3 mm Hg). PH (1–100 mg/kg, p.o.; δ -11 ±2 to δ -52 ± 9 mm Hg) was much less potent than PR and required a dose of at least 1.0 mg/kg to produce a significant BP reduction; their log-dose response curves were not parallel. Both agents caused a tachycardia commensurate with their BP reductions. PH had a shorter duration of action than PR and with both agents duration was dose related. PR and PH but not minoxidii interfered with the usual compensatory reflex BP response to vertical tilt in conscious SHR; however, the