Dietary Sodium and Renal α2-Adrenergic Receptors in Dahl Hypertensive Rats

William A. Pettinger Departments of Pharmacology and Internal Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas, 75235; National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland, 20205

Tamar Gandler Departments of Pharmacology and Internal Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas, 75235; National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland, 20205

Adela Sanchez Departments of Pharmacology and Internal Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas, 75235; National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland, 20205

Juan M. Saavedra Departments of Pharmacology and Internal Medicine, University of Texas Health Science Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas, 75235; National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland, 20205

Abstract

Dahl sodium-sensitive and resistant rats were fed low and high sodium diets. Renal plasma membrane α2-adrenergic receptor concentrations were greater (p<.05) in sensitive than in resistant rats while ingesting a low sodium diet. On a high sodium diet the α2 receptor concentration increased (p<.01) in sensitive but not in resistant rats. Since α2 receptors are located in proximal tubules at sites where nor-epinephrine induces sodium reabsorption, we postulate that this genetically determined abnormal receptor regulation could lead to exaggerated sodium retention and possibly high blood pressure.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Dietary Sodium and Renal α2-Adrenergic Receptors in Dahl Hypertensive Rats

Information for

Open access

Opportunities

Help and information

Dietary Sodium and Renal α2-Adrenergic Receptors in Dahl Hypertensive Rats

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature