In Vitro Action of Insulin on Erythrocyte Sodium Transport Mechanisms: Its Possible Role in the Pathogenesis of Arterial Hypertension

Abstract

The effects of insulin on sodium and potassium metabolism have been well known for many years; clinical observation and laboratory experience showed different results about the insulin effect on the sodium-potassium pump. Moreover, studies about the insulin effect on the sodium-potassium cotransport are not available. Therefore, the effects of insulin on Na,⁺K⁺ pump and Na⁺,K⁺ cotransport were evaluated. Results show that insulin inhibits Na⁺, K⁺ pump, while Na⁺, K⁺ cotransport is markedly activated. The possible link between pathogenesis of arterial hypertension in hyperinsulinemic subjects and present data is examined.

Key Words:

• insulin
• Na⁺,K⁺ pump
• Na⁺,K⁺ cotransport