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Abstract
Biosynthetic patterns of 18-OH-deoxycorticosterone (18-OH-DOC) and corticosterone (B) in adrenal tissue of Wistar-rats and two rat strains with salt-dependent hypertension (Dahl-, Sabra-rats) were measured by means of quantitative HPLC-analysis. The relative activity of 18-hydroxylation is expressed as the ratio 18-OH-DOC/ 18-OH-DOC + B, in the following called Q. Wistar-rats show a constant product ratio Q of 0.40 ± 0.01. Dahl-rats, however, exhibit typical differences between the two substrains. Adrenal tissue of salt-resistant (Dahl-R) rats produces significantly less 18-OH-DOC than tissue from salt-sensitive (Dahl-S) rats: Q = 0.17 ± 0.01 (Dahl-R) vs. Q = 0.37 ± 0.01 (Dahl-S). No such difference was observed between the two Sabra-substrains. This indicates, that other mechanisms than an altered 11ß-18-hydroxylation are involved in the salt-dependent hypertension of Sabra-rats.