The Central Effects of the Renin-Angiotensin System

Abstract

The acute administration of ANG II into the brain of experimental animals produces transient pressor effects, a marked increase in drinking, release of the antidiuretic hormone, increase in total peripheral resistance, a diuretic and natriuretic effect and an increase in sympathetic outflow.

The chronic administration of ANG II into a cerebrolateral ventricle produces sustained pressor effects only if 0.9% sodium chloride solution is used as the drinking fluid. The hypertension is due to an increase in total peripheral resistance which appears

Key Words:

• Brain Angiotensin
• Hypertension
• Sodium-potassium Pump
• Dipsogenic Activity
• Vascular Reactivity
• Sympathetic Outflow
• Natriuretic Hormone