The Hypothalamic-Angiotensin System: Location and Functional Considerations

Abstract

Improved immunohistochemical and quantitative microiontophoretic methods were used to characterise angiotensinergic and angiotensin-sensitive neurones in the paraventricular nucleus (PVN) of the rat. The results can be summarised as follows

1) Angiotensinogen was found in PVN neurones, astro-cytes in the diencephalon which make putative contacts with microvessels, and in cells of the choroid plexus.

2) Affinity-purified angiotensin II/III antibodies were used to locate immunoreactive All/III in large PVN neurones and their fibre tracts which

Key Words:

• Angiotensin II
• angiotensin III
• aminopeptidase inhibitors
• bestatin
• amastatin
• rat
• hypothalamus
• microiontophoresis
• immunocyto-chemistry