Opioid Modulation of Vasopressin Secretion in Conscious Rats

Takayuki Yamada Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Kazuwa Nakao Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan; Radioisotope Research Center, Kyoto University, Kyoto, 606, Japan

Hiroshi Itoh Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Gotaro Shirakami Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Akira Sugawara Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Yoshihiko Saito Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Masashi Mukoyama Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Hiroshi Arai Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Kiminori Hosoda Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Narito Morii Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Shozo Shiono Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

Hiroo Imura Second Division, Department of Medicine, School of Medicine Kyoto University, Kyoto, 606, Japan

show all

Abstract

To clarify the role of endogenous opioid peptides in the control of vasopressin (AVP) secretion, the effects of an endogenous k-agonist, leumorphin, derived from proenkephalin B and an opioid antagonist, naloxone, on AVP secretion were examined in conscious and freely moving rats. Intraperitoneal injection of nicotine markedly increased AVP secretion in rats. The nicotineinduced AVP secretion was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with leumorphin. Intravenous injection of naloxone significantly increased the basal AVP level and carbachol-induced AVP secretion. These results indicate that endogenous opioid peptides have an inhibitory effect on AVP secretion in rats.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Opioid Modulation of Vasopressin Secretion in Conscious Rats

Information for

Open access

Opportunities

Help and information

Opioid Modulation of Vasopressin Secretion in Conscious Rats

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature