Alpha-Form of Atrial Natriuretic Peptide Released from Dog Atrium During Atrial Distension

S. Akabane Departments of Cardiovascular Dynamics and Internal Medicine, National Cardiovascular Center, Research Institute, Suita, Osaka, 565, Japan

S. Kojima Departments of Cardiovascular Dynamics and Internal Medicine, National Cardiovascular Center, Research Institute, Suita, Osaka, 565, Japan

M. Kawamura Departments of Cardiovascular Dynamics and Internal Medicine, National Cardiovascular Center, Research Institute, Suita, Osaka, 565, Japan

T. Iida Departments of Cardiovascular Dynamics and Internal Medicine, National Cardiovascular Center, Research Institute, Suita, Osaka, 565, Japan

Y. Matsushima Departments of Cardiovascular Dynamics and Internal Medicine, National Cardiovascular Center, Research Institute, Suita, Osaka, 565, Japan

K. Ito Departments of Cardiovascular Dynamics and Internal Medicine, National Cardiovascular Center, Research Institute, Suita, Osaka, 565, Japan

Abstract

To assess the released form of atrial natriuretic peptide (ANP) during atrial distension, we compared the form of ANP before and during atrial distension in anesthetized dogs, using radio-immunoassay combined with high performance liquid chromatography (HPLC). When increasing the left atrial pressure (LAP) from 2, 2±0. 9 mmHg to 9.4±1.3 mmHg, the plasma ANP concentration in the coronary sinus was increased by 190% over the control, during left atrial distension. The major form of the released ANP extracted in the blood sample obtained from the coronary sinus was α-form. However other unidentified immunoreactive peaks, preceding and following the main peak were also discernible. These results suggest that the major form of ANP released during left atrial distension was the α-form.

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Alpha-Form of Atrial Natriuretic Peptide Released from Dog Atrium During Atrial Distension

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Alpha-Form of Atrial Natriuretic Peptide Released from Dog Atrium During Atrial Distension

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