Chronic Antihypertensive Drug Treatment Decreases Protein Kinase C Activity in Platelets from SHR

Kazuo Takaori First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, Japan

Hiromi Inariba First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, Japan

Satoko Itoh First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, Japan

Takatoshi Inoue First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, Japan

Yoshiharu Kanayama First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, Japan

Tadanao Takeda First Department of Internal Medicine, Osaka City University Medical School, Osaka, 545, Japan

Abstract

There is evidence that protein kinase C activity in platelets from adult SHR is significantly higher than this activity in age-matched WKY. In the present study, protein kinase C activity in the SHR was measured following antihypertensive drug treatment. Chronic administration of enalapril to SHR for 2 weeks decreased both systolic blood pressure and protein kinase C activity to the levels seen in the WKY. Similar results were obtained in case of chronic treatment of SHR with hydralazine or nifedipine. These results suggest that enhanced protein kinase C activity of SHR can be suppressed by lowering blood pressure by antihypertensive drugs.

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Chronic Antihypertensive Drug Treatment Decreases Protein Kinase C Activity in Platelets from SHR

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Chronic Antihypertensive Drug Treatment Decreases Protein Kinase C Activity in Platelets from SHR

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