Effects of Calcium and Deoxycorticosterone on Blood Pressure, Plasma Renin Activity and Vascular Reactivity in Spontaneously Hypertensive Rats

I. Pörsti Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

H. Wuorela Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

P. Arvola Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

P Säynävälammi Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

A K. Nurmi Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

H. Huhtala Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

P. Laippala Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

T. Metsä Ketelä Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

H. Vapaatalo Department of Biomedical Sciences and Department of Public Health, University of Tampere, P.O. Box 607, SF-33101, Tampere, Finland

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Abstract

The effects of calcium and deoxycorticosterone (DOC) on blood pressure, plasma renin activity (PRA), urinary sodium excretion and aortic responses were studied in spontaneously hypertensive rats (SHR). The animals (age 9 weeks) were divided into four treatment groups: control, calcium, DOC and DOC+calcium (n=12 and the mean systolic blood pressure 174–177 mmHg in each). Calcium was given as 1.5 % CaC1₂, in drinking fluid, and DOC trimethyl-acetate by weekly injections (25 mg/kg s.c.). During the 4–week study systolic blood pressure rose in all groups, but the increase was attenuated by calcium (final levels: control 201·3, calcium 186·3, DOC 206·2, DOC+calcium 203·2 mmHg, mean). PRA was reduced in both groups receiving DOC, but it was not affected by calcium.

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Effects of Calcium and Deoxycorticosterone on Blood Pressure, Plasma Renin Activity and Vascular Reactivity in Spontaneously Hypertensive Rats

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Effects of Calcium and Deoxycorticosterone on Blood Pressure, Plasma Renin Activity and Vascular Reactivity in Spontaneously Hypertensive Rats

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