Excitatory Amino Acid Receptors in the Paraventricular Hypothalamic Nucleus Mediate Pressor Response Induced by Carotid Body Chemoreceptor Stimulation in Rats

T. Kubo Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, Tokyo, 194, Japan

Y. Yanagihara Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, Tokyo, 194, Japan

H. Yamaguchi Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, Tokyo, 194, Japan

R. Fukumori Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, Tokyo, 194, Japan

Abstract

In urethane-anesthetized rats with spinal transection, antagonists of excitatory amino acid receptors, P2 purinoceptors and adrenoceptors were microinjected into the paraventricular hypothalamic nucleus (PVN) and their effects on the pressor response evoked by carotid body chemoreceptor stimulation were examined. Microinjections of the non-selective excitatory amino acid antagonist kynurenate, the non-NMDA receptor antagonist CNQX and the NMDA antagonist 2-

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Excitatory Amino Acid Receptors in the Paraventricular Hypothalamic Nucleus Mediate Pressor Response Induced by Carotid Body Chemoreceptor Stimulation in Rats

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Excitatory Amino Acid Receptors in the Paraventricular Hypothalamic Nucleus Mediate Pressor Response Induced by Carotid Body Chemoreceptor Stimulation in Rats

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