Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction

Hyun Bo KimDiscipline of Pathology, Redox Biology Group, The University of Sydney, Sydney, NSW 2006, Australia

Anu ShanuDiscipline of Pathology, Redox Biology Group, The University of Sydney, Sydney, NSW 2006, Australia;Vascular Biology, ANZAC Research Institute, Concord Repatriation General Hospital, Concord, NSW 2139, Australia

Sarah WoodDiscipline of Pathology, Redox Biology Group, The University of Sydney, Sydney, NSW 2006, Australia;Vascular Biology, ANZAC Research Institute, Concord Repatriation General Hospital, Concord, NSW 2139, Australia

Sarah N. ParryDiscipline of Pathology, Redox Biology Group, The University of Sydney, Sydney, NSW 2006, Australia;Vascular Biology, ANZAC Research Institute, Concord Repatriation General Hospital, Concord, NSW 2139, Australia

Michael ColletDiscipline of Pathology, Redox Biology Group, The University of Sydney, Sydney, NSW 2006, Australia

Aisling McMahonBiogerontology Groups, ANZAC Research Institute, Concord Repatriation General Hospital, Concord, NSW 2139, Australia

Paul K. WittingDiscipline of Pathology, Redox Biology Group, The University of Sydney, Sydney, NSW 2006, AustraliaCorrespondence[email protected]

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Abstract

Rhabdomyolysis (RM) caused by severe burn releases extracellular myoglobin (Mb) that accumulates in the kidney. Extracellular Mb is a pro-oxidant. This study tested whether supplementation with tert-butyl-bisphenol (BP) or vitamin E (Vit E, as α-tocopherol) at 0.12% w/w in the diet inhibits acute renal failure (ARF) in an animal model of RM. After RM-induction in rats, creatinine clearance decreased (p < 0.01), proteinuria increased (p < 0.001) and renal-tubule damage was detected. Accompanying ARF, biomarkers of oxidative stress (lipid oxidation and hemeoxygenase-1 (HO-1) gene and protein activity) increased in the kidney (p < 0.05). Supplemented BP or Vit E decreased lipid oxidation (p < 0.05) and HO-1 gene/activity and restored aortic cyclic guanylyl monophosphate in control animals (p < 0.001), yet ARF was unaffected. Antioxidant supplementation inhibited oxidative stress, yet was unable to ameliorate ARF in this animal model indicating that oxidative stress in kidney and vascular cells may not be causally related to renal dysfunction elicited by RM.

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This paper was first published online on Early Online on 27 June 2011.

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Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction

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Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction

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