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Free Radical Research Communications Volume 5, 1988 - Issue 2
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Original Article

A Comparison of the Free Radical Scavenging Activity of Leukotrienes and Prostaglandins

M. Chopra Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, El IXL, Scotland
,
J. J. F. Belch Department of Medicine, Ninewells Hospital, Dundee, Scotland
&
W. E. Smith Department of Pure & Applied Chemistry, University of Strathclyde, Glasgow, El IXL, Scotland
Pages 95-99 | Received 25 Apr 1988, Published online: 07 Jul 2009
 
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Abstract

The relative reactivity of leukotrienes and prostaglandins to free radicals and the superoxide ion generated by the photo oxidation of dianisidine have been assessed in vitro. Leukotrienes are effective general radical scavengers rather than superoxide scavengers, with the order of effectiveness LTD, > LTC4 > LTB4. Prostaglandins are relatively unreactive. It is suggested that this susceptibility to free radical attack may be one reason for the formation of chemotactic agents from leukotrienes rather than prostaglandins and this may be one part of the mode of action of these compounds in chronic inflammation.

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