Electrochemical Characteristics of Nitro-Heterocyclic Compounds of Biological Interest. II. Nitrosochloramphenicol

Abstract

The electrochemical Characteristics of nitrosochloramphenicol have been studied in aqueous buffer systems (pH 7.1) using direct current (d.c.) and differential pulse polarography. cyclic voltammetry and coulometric techniques. Up to 4 charge-transfer steps can be identified. The first reduction step is reversible both chemically and electrochemically. the charge-transfer product showing no tendency to undergo further reaction on the electrochemical time-scale. In contrast, the second reduction step is irreversible, with the product undergoing a fast following reaction to yield a redox-active species which was detected by cyclic voltammetry. From the data and by comparison with related systems. two reduction mechanisms are possible and are discussed.

Key Words:

• Nitrosochloramphenicol
• free radicals
• reduction
• cyclic voltammetry